… -based anti-inflammatory compound used for the treatment of … focus mainly on its inhibitory
effects on antioxidant defensive … to the identification of a variety of targets for AUR, and this …

… The aim of this study was a detailed functional characterization … ), a potent inhibitor of
GSTP1-1, and auranofin, gold phosphine … The strength of inhibition of the tested compounds was …

… peroxidase, glutathione-S-transferase, … the inhibition of TrxR, a computational investigation
at DFT level analyzed the ligand exchange reactions of auranofin with the potential target …

… The overall conclusion from our results is that TRi-1 and TRi-2 are more specific TXNRD1
inhibitors than AF, and we identify additional targets of the three drugs that should be …

… Auranofin is an antiarthritic gold phosphine compound that … in contrast to other described
targets 103 . Therefore, future … mechanism of enzyme inhibition played by auranofin on GSTs…

… of AMPK can inhibit the mammalian target of rapamycin (… In contrast, microsomal glutathione
S-transferase 1 (MGST1) … There have been various studies demonstrating that auranofin …

… relatively few agents that target cellular redox homeostasis to … clinically used antiarthritic
gold(I) drugs auranofin, approved … analogue that inhibits glutathione S-transferase pi isoform (…

… This study suggested that bacterial TrxR is the primary target of auranofin. Inhibition of
TrxR … and affects the corresponding protein functions, such as glutathione-S-transferase [120], …

… [104,105] Another compound enabling cells to overcome resistance to platinum based
drugs, shown to inhibit GSTP1 enzyme activity, is auranofin, a gold-phosphine compound [106]. …

… (GR), glutathione-S-transferase, 12 cysteine proteases, 13 … shown to be potently inhibited
by gold complexes. Interestingly, … and cell extracts, in comparison to auranofin, the gold(I) anti-…